›› 2012, Vol. 24 ›› Issue (2): 148-152.doi: 10.3969/j.issn.1004-616x.2012.02.016

• 检测研究 • Previous Articles     Next Articles

Acute toxicity and mutagenicity of Sacha Inchi oil

HUANG Chao-pei，FU Wei-zhong，PENG Liang，WANG Yan-wu，HE Li，LI Bin   

  1. Guangxi Center for Disease Prevention and Control, Nanning 530028, Guangxi, China
  • Received:2011-07-01 Revised:2011-09-14 Online:2012-03-30 Published:2012-03-30
  • Contact: 黄超培

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Abstract: OBJECTIVE: To study the safety of Sacha Inchi oil. METHODS：Oral toxicity test (3 administrations within 24 h，total dose 54 g/kg)，Ames test (5 000，1 000，200，40，8 μg/plate)，micronucleus test of bone marrow PCE cell and sperm shape abnormality test in mice (10，5，2.5 g/kg) were used to study the acute toxicity and mutagenicity of Sacha Inchi oil. RESULTS：The oral LD50 of Sacha Inchi oil in mice was more than 54 g/kg. No increase in the number of revertant colonies was found in Ames test. The micronucleus rates and sperm abnormality rates at all doses were not significantly different from the negative control. CONCLUSION：The Sacha Inchi oil when given orally showed no acute toxicity and mutagenicity under our experimental conditions.

Key words: Sacha Inchi oil, acute toxicity, mutagenicity